|Systemic Sclerosis is a type of connective tissue disorder. In this disease there is deposition of extra collagen under the skin. This leads to thickening of the skin cells. This also results in the injuries occurring in the arteries. This leads to disorders in the circulatory system as the oxygenated blood cannot be circulated to all the parts of the body. This not only occurs in the skin but also in various organs like kidneys, liver, etc. leading to deregulation of body systems.
Review articles are the summary of current state of understanding on a particular research topic.
Review article comes in the form of systematic reviews and literature reviews and are a form of secondary literature. Systematic reviews determine an objective list of criteria, and find all previously published original research papers that meet the criteria. They then compare the results presented in these papers. Literature reviews, by contrast, provide a summary of what the authors believe are the best and most relevant prior publications.
The concept of "review article" is separate from the concept of peer-reviewed literature. It is possible for a review to be peer-reviewed, and it is possible for a review to be non-peer-reviewed.