"The molecular display method to prepare target proteins is especially well established for use with the yeast Saccharomyces cerevisiae , and it is also known as âcell surface engineeringâ. For example, an antigen from red sea bream iridovirus (RSIV) was displayed on the surface of yeast cells to create an oral vaccine for use in fisheries. Ã-glucan, an abundant component 1 of the yeast cell wall, is thought to function as an adjuvant. Further, yeast is a generally recognized as safe (GRAS) organism, suitable for the preparation of oral vaccines without antigen purification, while that process is required for recombinant proteins produced by E. coli . Therefore, molecular display could provide a method for production of antigenic proteins selected in proteome studies that is more rapid and convenient than conventional vaccine production methods.
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Citation: Shibasaki S, Karasaki M, Ueda M (2014) Combining Proteomic Strategies and Molecular Display Technology for Development of Vaccines against Candida albicans. J Proteomics Bioinform 7: 134-138."
Last date updated on July, 2014