"The molecular display method to prepare target proteins is especially well established for use with the yeast Saccharomyces cerevisiae , and it is also known as ââ¬Åcell surface engineeringââ¬Â. For example, an antigen from red sea bream iridovirus (RSIV) was displayed on the surface of yeast cells to create an oral vaccine for use in fisheries. ß-glucan, an abundant component 1 of the yeast cell wall, is thought to function as an adjuvant. Further, yeast is a generally recognized as safe (GRAS) organism, suitable for the preparation of oral vaccines without antigen purification, while that process is required for recombinant proteins produced by E. coli . Therefore, molecular display could provide a method for production of antigenic proteins selected in proteome studies that is more rapid and convenient than conventional vaccine production methods.
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Citation: Shibasaki S, Karasaki M, Ueda M (2014) Combining Proteomic Strategies and Molecular Display Technology for Development of Vaccines against Candida albicans. J Proteomics Bioinform 7: 134-138."
Last date updated on July, 2025
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