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Research Article Open Access
Infectious diseases are caused by pathogenic microorganisms, such as bacteria, viruses, parasites, or fungi. Diseases can spread, directly or indirectly, from one person to another. About one-fourth of all the medicines we use, come from rainforest plants. However, scientific studies have been conducted only to a limited extent with few medicinal plants. In the present communication, the successive ethanolic extract of the stem bark of Ziziphus xylopyrus Willd. (Family: Rhamnaceae) was prepared and evaluated for its antimicrobial potential against different gram positive bacteria, namely Staphylococcus aureus ML-59, Salmonella typhimurium NCTC 74, Staphylococcus aureus 29737, Bacillus lycheniformis 10341 and gram negative bacterial strains, namely Escherichia coli K-12 ROW, Shigella sonnei 2, Shigella boydii 8, Vibrio cholera 811, Vibrio cholera 854, Vibrio alginolyteus. The potential antibacterial activity against different bacteria was examined by minimum inhibitory concentration (MIC) and zone of inhibition (ZOI) analysis. MIC values compared with control and zone of inhibition (ZOI) values compared with standard ciprofloxacin. The results revealed that, the ethanolic extract is potent in inhibiting bacterial growth of both gram negative and gram-positive bacteria and comparable with the standard (ciprofloxacin). The 200 μg/ml of ethanolic extract showed the best antibacterial activity as compared to the other concentrations. Hence, this plant can be further subjected to isolation of the therapeutic antibacterials and further pharmacological evaluation.
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Author(s): Basanta Kumar Jena, Bhabagrahi Ratha, Subrat Kar, Satyaranjan Mohanta, Amit Kumar Nayak