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Research Article Open Access
Leaf samples of Wattakaka volubilis were used to examine their antidiabetic effect on Swiss Albino rat with different concentrations of this selection. Diabetes was induced in Swiss Albino rats by administration of alloxan monohydrate (150 mg/kg, i.p). The ethanol extract of W.volubilis at a dosage of 150 mg/kg of body weight was administered in individual dose per day to diabetes induced rats for a period of 14 days. The issue of ethanol extract of W.volubilis leaf extract on blood glucose, serum enzymes (serum glutamate pyruvate transaminases (SGPT), serum glutamate oxaloacetate transaminases (SGOT) and alkaline phosphatase (ALP)) and antioxidant enzymes (catalase (CAT) and glutathione peroxidase (GPx)) were appraised from the diabetic rats. The ethanol extract of W. volubilis leaf elicited significant reductions of blood glucose (p<0.01), the extracts also caused a significant growth in plasma insulin and antioxidant enzymes in the diabetic rats. The survey confirmed that W.volubilis effective in scavenging free radicals and has potential to be powerful antioxidant ability / antidiabetic effects in alloxan induced diabetic rats.
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Author(s): K. Sridhara Vishnusithan, J. Jerome Jeyakumar, M. Kamaraj, B. Ramachandran
Wattakaka volubilis, antidiabetic, antioxidant property, Diabetic Amyotrophy,Diabetes Research and Clinical Practice,Diabetes Research and Clinical Practice