alexa Abstract | Anti-inflammatory and Analgesic Activity of Methanolic Extract of Medicinal Plant Rhodiola rosea l. Rhizomes


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Abstract

Rhodiola rosea L. (Crassulaceae) have been used as traditional medicines that can increase someone’s physical strength, work productivity, longevity and resistance to high altitude sickness, fatigue, depression, anaemia, gastrointestinal ailments, infections, and nervous system disorders. The objective of this study was to evaluate the anti-inflammatory and analgesic activities from the methanolic extract of the rhizomes of Rhodiola rosea. Crude methanolic extract of the herb Rhodiola rosea were prepared and analyzed for its pharmacological activity. Swiss albino mice are used for acute toxicity study and also analgesic property of the extract by using Tail flick, Acetic acid induced writhing reflex and tail immersion method. Male Wister rat model are used to detect anti-inflammatory activity of the extract using carrageenan induced rat paw edema. After experiment statistical analysis like one way anova (non-parametric), Dunnet’s test was done. Results are plotted in graph and from this the effective activity of the plant is determined. The orally administered methanolic extract of Rhodiola rosea demonstrated a significant analgesic and anti-inflammatory in animal model. The findings in the study suggest that the methanolic extract of the herb Rhodiola rosea possesses analgesic and anti-inflammatory activities. This results may prove the fact that the herb may be used as analgesic and anti-inflammatory along with its adaptogenic properties.

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Author(s): Avijit Chatterjee, Biswarup Sen, Sumanta Das, Tapan Kumar Chatterjee

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