alexa Abstract | Assessment of Potential Antioxidant Activity of Polyphenolic Fraction Separated from Acalypha Indica Leaves: An In vitro Approach

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The free radicals are generated in normal cellular metabolic events .However they may be produced more in disease conditions when they directly interact with the bio molecules are dangerous to the normal life because they alter genetic material. Free radicals induce permanent modifications in genetic material that may lead to mutagenesis, carcinogenesis and aging. The prevention or treatment of diseases has direct link with antioxidants which can reduce the effect of free radicals. The phenolic compounds are functionally potent antioxidants and they have the ability to scavenge reactive oxygen species (ROS)/ reactive nitrogen species(RNS), suppress the ROS/RNS formation by inhibiting relevant enzymes, chelates trace metal elements responsible for free radical generation and up regulates or protects the antioxidant defense system. In this study, we attempted for the separation of Polyphenolic fraction from Acalypha indica leaves and tested for its antioxidant activity employing DPPH, H2O2 assays and also to assess its reducing power, total antioxidant power. The outcome of the results from this study showed that Polyphenolic fraction from the Acalypha indica leaves scavenges the in vitro free radicals to their stable forms such as DPPH radical to DPPH, Mo (VI) to Mo (V), ferric cyanide complex to ferrous form and hydrogen peroxide to water. The polyphenolic fraction has the reduction power against free radicals which suggests further studies to take up in in vivo for the treatment of various diseases due to free radicals generation.

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Author(s): Sahukari Ravi, Bhasha Shanmugam, Singamala Hari Prasad, Ganjikunta Venkata Subbaiah, Kesireddy Sathyavelu Reddy

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