alexa Abstract | Central and Peripheral Acting Analgesic Activity of Karunkali Ver (Acacia Catechu)


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Abstract

Diabetic neuropathy, Equated to Vathakarshanam in Siddha is one of the complications of diabetes which cripple the patients. In India, the prevalence of diabetic neuropathy has been estimated as high as 62% based on subjective complaints, 55% by signs and 100% by nerve conduction studies. On an average, medical expenditures are thought to be 2.3 times higher in diabetics as compared with non diabetics. The present study was aimed at evaluation of the central and peripheral acting analgesic activity of total aqueous extract of root of Acacia catechu (karunkali ver – a Siddha Drug) in mice by Eddy’s hot plate method and Writhing test. Karunkali (Acacia catechu) is an herb described in Gunapadam mooligai vaguppu. It is therapeutically quoted for Diabetes (Mathumegam) and Thimiru (Neuritis). The results of hot plate model indicated that the total aqueous extract of karunkali ver Kudineer (kvk) shows a significant increase (p< 0.01) in reaction time at a 3, 4 and 6 hours comparable to the reference drug Pentazocin but lesser (p< 0.05) at 2 hour. The tail immersion and hot plate test reveal that this has high analgesic activity. The bio chemical parameters never show any untoward changes during study period. Karunkaliver Kudineer showed maximum analgesic effect after 90min of administration. In conclusion, the Karunkaliver Kudineer was proved as a safe Siddha remedy for the treatment of algesia at the dose level of 4ml/kg body weight orally.

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Author(s): S. Umera, K. Kanagavalli, P. Parthiban, J. Anbu P, Sathiya Rajeswaran

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