alexa Abstract | Challenges in Protein Formulation Focused on Extrusion-Spheronization Process


Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access

Abstract

Biotechnology revolution had led the overcoming of different types of therapeutic protein because of their chemical structure can perform specific reactions in the body, increasing efficacy and decreasing side effects. Numerous efforts were made to optimize the physicochemical properties of the proteins used for therapeutic and studied different methods for an effective administration of the protein contained in the medicine, evaluating different routes of administration to achieve the desired therapeutic effects. The delivery system for oral pharmaceutical proteins and peptides is still in development stage. There are number of limitations to oral delivery of proteins such as barriers to peptide bioavailability after oral administration, intestinal membrane permeability, size, intestinal and hepatic metabolism and solubility. Pellets have shown great potential in the delivery of proteins/peptidal drugs. Some strategies of development of oral protein and peptides has always been challenged, optimizing the safety and efficacy while ensuring the ability to manufacture the drug while maintaining quality and stability. The pelletization techniques have been reviewed in numerous papers, is a technique that enables the formation of spherical beads or pellets with a mean diameter usually ranging from 0.5-2.0 mm. Pellets are prepared by different techniques, such as extrusion and spheronization. This review discusses challenges in protein formulation that have been used to prepare pelletized dosage forms using the extrusion-spheronization process

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): S. Ravetti, L.Y. Hergert, M. Sparo, S.F. Sanchez Bruni, S.D. Palma

Recommended Journals

Share This Page

Additional Info

Loading
Loading Please wait..
 
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords