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Mini Review Open Access
Osteoarthritis is one of the most debilitating clinical entities we come across in outpatient practice. It is a clinical endpoint of a number of pathophysiologic changes associated with age, joint trauma and alteration of biomechanics resulting in joint failure. The presentation of osteoarthritis represents a multitude of factors like joint damage, irregulated immune response to damage and chronic inflammatory response. Several Pathogens associated molecular patters (PAMP) and Damage associated Molecular pattern (DAMP) due to unregulated innate response has been implicated in the progression of the disease.