alexa Abstract | Design and Characterisation of Chloramphenicol Ocular Insert for Ocular Drug Delivery


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Research Article Open Access

Abstract

The purpose of the present work was to develop an ophthalmic drug delivery system using different gelling agents with different mechanisms for ocular inserts of Chloramphenicol, an antibiotic drug. PVA a backing membrane and gelling agent Methyl cellulose were employed for the formation of ocular inserts along with HPMC as a hydrophilic agent. The formulations F1 to F4 and F5 to F8 were evaluated for Uniformity of thickness, Uniformity of weight, Surface pH, drug content, In vitro drug release, and Sterility test. The results were found to be satisfactory in terms of surface pH, weight variation, and drug content. The IR study shows polymers compatible with the drug. The in-vitro percent cumulative drug release (%CDR) in 10 hours study was 99.97%, 101.9%, 100.45% and 100.2% for formulations F1, F2 , F3 and F4 and was 103.5%, 103.16% ,99.99 %and 105.9% for F5, F6 and F7, F8 formulations respectively. Among these the F3 and F7 formulations showed maximum sustaining effect. Percent drug content of 98.7% and 97.3% was found maximum in the F3 and F8 formulation.

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Author(s): Priyanka Khokhar

Keywords

Ocular inserts for ophthalmic systems, chloramphenicol, polyvinyl alcohol, methyl cellulose, HPMC, Liver Inflammation

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