alexa Abstract | Design and Characterization of Enteric Coated Pellets of Aspirin Using Hot-Melt Coating Technique

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Generally enteric coating is organic solvent based dispersion or solution of polymer which is equally hazardous to the environment and operators. Hot-melt coating (HMC) devoid the use of solvents and hence it is cheap, environment friendly, safe and rapid process. The objective of present study was to ensure the suitability of HMC as an enteric coating technique. Aspirin was used as model drug due to its stomach mucosal irritation and ulcerogenic property. Pellets of aspirin prepared by extrusion-spheronization technique were used as coating substrate. Stearic acid (SA) and palmitic acid (PA) were evaluated as enteric HMC materials. HMC was carried out in a specially modified coating pan and by applying SA and PA in molten state onto preheated pellets to achieve a coating level of 5-10% w/w. Hot-melt coated pellets were evaluated for disintegration pH and in vitro dissolution in the pH range 1.2 to 6.8, along with basic micromeritics. Scanning electron microscopy (SEM) of coated pellets showed a uniform and smooth coating. These results indicated that HMC of both SA and PA exhibited very good enteric coating ability. The coated pellets showed negligible drug release in acidic pH. As the pellets were subsequently transferred to a higher pH level, a gradual increase in release of the drug from the pellets was observed with increasing pH of the dissolution media. The release was dependent upon coating extent, providing sustained enteric release as opposed to abrupt release with mixed release kinetics

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Author(s): *S. G. Sudke, D. M. Sakarakar

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