alexa Abstract | Design and Development of Pravastatin Sodium Fast Dissolving Films from Natural Mucilage of Ocimum Bacilicum Seeds

Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access


The present research work, aims to prepare and evaluate the fast dissolving oral films containing Pravastatin sodium, an anti hyperlipidemic drug using different ratios of polymers, Hydroxypropyl methylcellulose E3,E5,E6, Polyvinyl alcohol and Ocimum bacilicum mucilage powder. The film was prepared by solvent casting technique using Glycerine and Propylene Glycol, PEG 400 as plasicizers, Aspartame as sweetner , Eugenol as flavouring agent and Xylitol, Mannitol,Sorbitol and as Film modifiers. The study examines the influence of polymers ratio on physicochemical properties and drug release potential of films. Pravastatin sodium, a HMGCoA- Reductase inhibitor with the absorption rate of 34% but the bioavailability is 45% due to its first pass effect, the half life of the drug was around 1.5-2 hours. The present study investigated the possibility of developing Pravastatin sodium fast dissolving films allowing fast, reproducible drug dissolution in the oral cavity, thus bypassing first pass metabolism to provide rapid onset of action of the drug. The films were thin, smooth, flexible, and uniform in drug content, weight and thickness as observed from low SD values. The film formulation, (F14) consisting of polyvinyl alcohol and ocimum bacilicum mucilage powder in the ratio of (1.5%: 0.5%) was found to be suitable in the form of fast dissolving oral film. The optimized formulation, F14 showed less disintegration time and faster drug release. All the systems were found to be stable with respect to drug content as well as physical changes at at 40 ± 2°C ; Relative Humidity (RH) Maintained at 75%±5%RH.

To read the full article Peer-reviewed Article PDF image

Author(s): Ramani Gade, Aparna Aynampudi1, Anitha Makineni, T. E. G. K. Murthy, Chandu Babu Rao, Sreekanth Nama

Recommended Journals

Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version