alexa Abstract | Development and Evaluation of Herbal Fast Dissolving Tablets of Tectona grandis Linn


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Abstract

Fast dissolving Tablets are disintegrating and/or dissolve rapidly in the saliva without the need for water. FDTs are convenient to be manufactured and administered, free of side effects, offering immediate release and enhanced bioavailability, to achieve better patient compliance. Fast disintegrating tablets have been formulated for pediatric, geriatric, and bedridden patients. FDTs can be prepared by different methods as direct compression, freeze-drying, spray drying, sublimation and wet granulation method. Herbal drugs comprise of a major share of all the officially recognised systems of health in India. The popularity and usefulness of the formulation resulted in development of several FDT technologies. The herbal extract of Tectona grandis Linn is used in this formulation. The aim of this study was to formulate FDTs with sufficient mechanical integrity and to achieve faster disintegration in the oral cavity without water. To achieve this goal, MCC is used as diluent and sodium saccharin as sweetening agent for the formulation of tablets. Attempts were made to enhance dissolution rate along with faster disintegration using superdisintegrants like Crospovidone, Sodium starch glycolate (SSG)and mixture of crospovidone and sodium starch glycolatein the formulation of tablets. The tablets were subjected to weight variation, drug content uniformity, hardness, friability, wetting time, In vitro dispersion time,In vitro drug release studies and In vivo studies. In vivo studies showed that formulation F1 has antidiabetic activity.

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Author(s): Amrita A. Kagalkar, Basavaraj K. Nanjwade, R. S. Bagli

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