alexa Abstract | Dual inhibition of cholinesterase enzyme by an aqueous extract of Hibiscus rosa sinensis L.

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Among many Indian medicinal plants, Hibiscus rosa sinensis has been used from centuries in treating liver disorder, high blood pressure, headache and other diseases associated with central nervous system. In Indian ayurvedic system of medicine this plant has been considered to be a brain tonic. In present study, an aqueous extract of Hibiscus rosa sinensis was assessed for their anti-cholinesterase activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BUChE). Ellman’s assay was used for inhibition study of cholinesterase enzyme. Our study demonstrated that an aqueous extract of this plant significantly inhibited both AChE and BUChE enzymes in a concentration dependent manner. An aqueous extract of Hibiscus rosa sinensis showed 62.02%±0.03 (SEM) inhibitory activity against AChE and 57.83%±0.05 (SEM) inhibitory activity against BUChE enzymes respectively. The IC50 value calculated from the percentage inhibition curve was 48.61μg/mL and 70.52μg/mL against AChE and BUChE respectively. These result demonstrated that an aqueous extract of Hibiscus rosa sinensis moderate AChE and BUChE activity. In conclusion, the present study indicated that an aqueous extract of Hibiscus rosa sinensis has got a potential dual anti-cholinesterase activity and can be explored further for isolation of potential therapeutic phytoconstituents that will be useful in improving memory and other cognitive function associated with the cholinergic system.

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Author(s): Mohammad Nazool, Suresh Kumar

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