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Research Article Open Access
Butylparaben is a widely used compound as a preservative in many pharmaceuticals and personal care products (PPCP). The high rate of human exposure to this chemical has been of growing concern as it is found to exhibit estrogenic activity in many in vivo and in vitro studies. Studies have shown that butylparaben exhibits reproductive toxicity affecting organs like uterus, ovary, testis and mammary glands. In vivo effect of butylparaben on ovarian weight has mostly been studied in CD1 and CF1 mice. It is found in many experimental studies that there are strain differences in sensitivity of rodents to different endocrine disrupting substances including butylparaben. In this experiment sensitivity of butylparaben exposure on ovary of C3H albino mice was studied considering change in ovarian weight of C3H albino mice taking 5 different doses of Butylparaben of 10 mg/Kg body weight/day, 50 mg/Kg body weight/day, 100 mg/Kg body weight/day, 500 mg/Kg body weight/day, 1000 mg/Kg body weight/day. The C3H albino mice were grouped as vehicle control (olive oil), positive control (estradiol) and the above five different doses of Butylparaben and were administered the doses for 7 consecutive days through subcutaneous route of administration. After the short term exposure of 7 days, butylparaben was found to exert a dose dependent change on ovarian weight of C3H albino mice.
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Author(s): Pallabi Goswami, J. C. Kalita