alexa Abstract | Effect of Excipient Gelucire 44/14 on the Intestinal Transport of Diltiazem Hydrochloride in Male Wistar Rat
ISSN ONLINE(2319-8753)PRINT(2347-6710)

International Journal of Innovative Research in Science, Engineering and Technology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access


Excipients play a crucial role in drug disintegration, dissolution, absorption, distribution and transport. They are used in pharmaceutical formulations to modulate drug transport by multiple mechanisms including inhibition of intestinal P-gp. The main aim of this work was to investigate the effects of Gelucire 44/14 on the P-gp-mediated transport of Diltiazem a CYP3A4 substrate across the rat intestine.Diltiazem is mainly used in the treatment of hypertension and angina pectoris. It is mainly metabolized to desacetyl-Diltiazem and desacetyl-N-demethyl-Diltiazem in which CYP3A mediates this N-demethylation and desacetylation. Everted and non-everted sac methods were used to study the transport of Diltiazem across the rat intestine (duodenum, jejunum and ileum). The rats were treated with Gelucire 44/14 using different concentrations (0.5%, 1%).The rats were sacrificed by using anesthetic ether. The intestinal segments were isolated and used for the studies. The probe drug (Diltiazem) solution 10 mg/mL was placed in the isolated intestinal sac and placed in buffer (Dulbecco’s). Samples were collected periodically. The drug content was estimated using high performance liquid chromatography method (HPLC).Control experiments were also performed. The transport of Diltiazem increased in case of non everted studies and exsorptionvalues were found to decrease compared to control incase of everted studies. Results reveal that gelucire 44/14 at 1% concentration inhibit P-gp action effectively when compared to gelucire 44/14 at 0.5% concentration.

To read the full article Peer-reviewed Article PDF image

Author(s): Shravan Kumar Y*, Shilpa S,Naresh N and Avinash M


Diltiazem, Gelucire44/14, Drug transport mechanisms, Everted, Non-everted, Exsorption and High Performance Liquid Chromatography method (HPLC)., Drug

Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version