alexa Abstract | Effect of Konjac Glucomannan on Hyperuricemic Rats
ISSN: 2321-6204

Research & Reviews: Journal of Food and Dairy Technology
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access

Abstract

Objective: The effect of konjac glucomannan (KGM) on hyperuricemic rats was studied.

Method: To establish a hyperuricemic model, rats in experiment groups were orally administrated with adenine and potassium oxonate every morning and continuously fed diets containing 20% yeast. Rats in positive drug group and KGM groups were orally administrated with benzbromarone and KGM respectively every afternoon. Blood was collected weekly and rats were sacrificed at 4th week, the biochemical indexes and histological analysis were measured.

Results: During the experiment, the level of uric acid (UA), Creatinine (Cr) and blood urea nitrogen (BUN)in model group increased significantly, indicating a hyperuricemic model was established successfully. But the level of the three indexes in positive drug group and KGM groups were lower to different degrees. UA in middle group exhibited the lowest level and had no significant with that of control group in the end. Besides, the activities of serum xanthine oxidase (XOD) and serum adenosine deaminase (ADA) in model group gradually increased and had significant difference with that of control group. KGM could significantly decrease the activities of XOD and ADA in serum and in liver, especially at middle dose. However, the activity of guanine deaminase (GD) did not have a significant fluctuation either in serum or liver during the experiment. Pathological analysis of kidneys showed KGM caused a strong reduction in the number of urate crystal, rats in high dose group had the lightest renal histological lesion.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Yuan Zhang, Xin Wu, Tiangang Shuai, Chunmei Wu, Jiujun Shen, Geng Zhong

Keywords

Konjac glucomannan, Hyperuricemia, Uric acid, Xanthine oxidase, Adenosine deaminase, Urate crystal, Renal lesion, Analysis for Novel and Safe Ingredients, Advance in Meat Processing, Food Safety & Regulations, Food Packaging Companies & Machinery, Beverage Industry Market Analysis, Dairy Industry Market Analysis, Food Industry Market Analysis, Meat Industry, Food Management, Processing and Preservation, Nutrigenomics, Milk Product, Food-Borne Pathogens, Food Quality, Food Microbiology and Fermentation, Food Chemistry and Biochemistry, Dairy Technology and Dairy Byproducts, Bulk Scale Processing and Production, Organic Dairy Farming

Share This Page

Additional Info

Loading
Loading Please wait..
 
 
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords