alexa Abstract | Effect of the Standardized Extract of Holarrhena Antidysenterica Seeds against Steptozotocin-Induced Diabetes in Rats


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Abstract

Holarrhena antidysenterica is found in Himalayan and sub-Himalayan tracts and is used traditionally for a range of health disorders, including colic, diarrhea, dysentery, constipation, flatulence, and urethrosis, as well as being considered functional as carminative, antispasmodic, astringent, anthelmintic, lithotriptic, diuretic, aphrodisiac, tonic, cardiosuppressant, and antihypertensive, antimutagenic, antibacterial and immunomodulatory properties. In this study, the effects of seeds of H. antidysenterica on fasting blood glucose levels in streptozotocin induced diabetic rats were examined, together with its effects on the lipid profile in-vivo. The oral glucose tolerance test revealed that animals treated with seeds of ethanolic extract of H. antidysenterica showed significant reductions in plasma glucose level compared with control group treated with gum acacia. H. antidysenterica seeds induced noteworthy reduction in serum glucose level in streptozotocin diabetic rats after 14 and 21 days, reducing the glucose concentration by 39.7 and 48.0%, respectively, when administered at 300 mgkg−1. When administered to streptozotocin induced diabetic rats at 300 mgkg−1 H. antidysenterica seeds had strong effects on their lipid profile by significantly decreasing total lipid, triglyceride and cholesterol. This pharmacological activity investigation has confirmed that H. antidysenterica seeds confers moderate defense against diabetes in-vivo. In addition, the potential of H. antidysenterica seeds to reduce triglyceride and total cholesterol levels while increasing high density lipoprotein may contribute to its beneficial effects in diabetic rats.

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Author(s): Vinay Kumar Pathak, Anup Maiti, Shyam Sundar Gupta, Ila Shukla, Ch. V. Rao

Keywords

Cholesterol, glucose, Holarrhena antidysenterica, streptozotocin, triglyceride, Diabetes Research and Clinical Practice,Diabetes Research and Clinical Practice

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