alexa Abstract | Effect of Vitamin E and C plus Reduced Glutathione in Treatment of Diabetic Nephropathy

Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access


Diabetes has describes, a group of metabolic diseases due to high blood sugar. Their uncontrolled lead to prolonged hyperglycemia resulting in long-term microvascular/macrovascular complications; and nephropathy is one of them. Objective: To evaluate the combine effect of antioxidant vitamins E and C plus reduced glutathione in diabetic nephropathy. Method: A randomized, open controlled clinical trial was conducted on 216 diabetic nephropathy patients who have had diabetes for at least 5 years. Result: 216 patients were selected and divided in to four groups such as positive control, vitamin, reduced glutathione and combination of vitamin E and C plus reduced glutathione. After 4 months supplementation of vitamin E and C plus reduced glutathione, it was found that the, vitamins and reduced glutathione treated groups shows significant (p<0.009 and p<0.002) decreased microalbuminuria levels from 33.2±2 to 30.5±2 and 31.4±2 to 30.1±1 as compared to control group. Interestingly, treatment of glutathione plus vitamins exhibited significant decreased (p<0.001) values from 33.3±2 to 27.2±2. Similarly, its effect on total protein shows significant difference (p<0.01 and p<0.05) decline in level from 8±0.4 to 7.6±0.3; 7.8±0.3 to 7.5±0.3 in vitamin and glutathione plus vitamin combination as compared to control and glutathione group alone. Conclusion: Diabetes is a chronic illness that requires a combine effect of treatment regimen for better glycemic control and to prevent its complications. So it has been suggested that initiating therapy with combination of antioxidants vitamin E and C plus reduced glutathione significantly lowers urinary albumin excretion rate and total protein in diabetic nephropathy.

To read the full article Peer-reviewed Article PDF image

Author(s): V. G. Kuchake,C. D. Upasani


Diabetic Nephropathy, vitamin E, Vitamin C, reduced glutathione, Diabetic Amyotrophy,Diabetes Research and Clinical Practice,Diabetes Research and Clinical Practice,Diabetic Nephropathy

Recommended Journals

Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version