alexa Abstract | Evaluation and Management of Drug-Drug Interactions in Ambulatory Patients

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Aim: To identify, monitor and manage Drug-drug interactions (DDI’s). Objective: The main objective of the study is to identify DDIs in out-patients and to categorize the severity, onset and MOA of drug interactions and to provide guidance regarding therapeutic management. Methods: The study is a Prospective Observational study done for a period of 12 months from December 2013 to December 2014 at the Pharmacist Patient Counselling Department of Rohini Super Speciality Hospital. Patients who visited the hospital with different diseases were reviewed; demographic details are collected, documented and analyzed for DDIs in Micromedex, and Lexicomp. Results: A total of 360 prescriptions were reviewed, enrolled 153 (42.5%) Prescriptions which met the study criteria and a total of 328 DDI’s were found. Male shows higher DDI’s i.e. 200 (60.97%) DDI’s. Based on severity moderate shows higher, i.e. 178 (54.26%) and not specified onset shows higher, i.e. 150 (45.73%) of DDIs. When DDI’s categorized based on MOA, PK interactions were 256 (78.04%). In managing DDI’s the methods to be followed were 114 (34.75%) Avoid combination for long term use and specific lab parameters must be monitored. Most common DDI’s were associated with NSAIDS 182, antidepressants 120 and H2-receptor antagonists 95. Conclusion: On evaluation, the majority of DDIs found to have not specified onset and moderate severity. An Increase in the number of drugs in prescription showed an increase in the number of DDIs and managing them by avoiding combination for long term use has shown greater impact in improving health related quality of life.

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Author(s): Pragathi Devireddy, Swarna Rekha P, Kamala S, Venkateswarlu K

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