alexa Abstract | Evaluation of Antitubercular Activity of Methanolic Extract of Citrus Sinensis


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Abstract

Tribal community are using their traditional knowledge system to cure various diseases. They use natural source of drugs through trial and error method and the process is experienced over hundreds of years, this says that the medicinal plant shave been in the focus as lifesaving drugs right from the beginning of the human civilization. Citrus sinensisis one such drug which has a strong research support of its use in biological activities such as antityphoid activity, antidiabetic activity, anticarcinogenic activity, antiproliferative activity, antioxidant activity, antibiotic activity, antifungal activity, antioxidant, anxiolytic effect, anti-lipidperoxidative effect, anti-inflammatory, lipoxygenase inhibitor, amylase inhibition, urease inhibition, Anti-hyperthyroidism, trypsin inhibition, inotropic effect, anti-arthritic, cardio-protective, anti-asthmatic, depression treatment, hepatotoxicity treatment, thrombosis treatment and rheumatic disease treatment. Citrus sinensisis a well-known herb which is found in the tropical and subtropical regions of India, China, Northern Australia and New Caledonia. Since Citrus sinensis has shown a wide variety of medicinal importance, we have here tested antitubercular activity by using Micro-plate Alamar Blue Assay (MABA) method.The dried peels of Citrus sinensiswereinitiallyde-fated and then were subjected to the methanolic extraction. The methanolic extract obtained was dissolved in various solvents such as water, methanol, ethanol, chloroform, diethyl ether separately and were subjected to evaluation of antitubercular activity against Mycobacterium tuberculosis by Microplate Alamar Blue Assay (MABA) method. The results concluded that the extract dissolved in water as solvent showed significant activity at 50μgm/ml.

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Author(s): Manish K,Mahesh AR, M Somashekhar

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