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Research Article Open Access
In this modern era, gastrointestinal disorders are the universal problem. Peptic ulcer is one of the major diseases affecting the human population. It develops due to the imbalance between aggressive factors like acid, pepsin, H. pylori and bile salts and defensive factors like mucous, bicarbonate, blood flow, epithelial cell restoration and prostaglandins. The anti-ulcer activity of Aqueous Extract of Piper nigrum and Ferula foetida (AEPF) was evaluated by using the experimental models of acute gastric lesions induced by aspirin and pylorus ligation in rats, cold restraint stress and cysteamine induced duodenal ulceration. Animals pre-treated with doses of 100 mg/kg, 200 mg/kg and 400 mg/kg of AEPF were statistically analyzed and compared to the standard and control group with the parameters like volume of gastric secretion, total acidity and ulcer index. The results suggested that AEPF significantly decreased volume of gastric acid secretion, total acidity and ulcer index in comparison with standard drug Omeprazole. AEPF shown significant reduction in lesion index, total affected area and percentage of lesion in comparison with control group in aspirin induced ulcer in experimental models. The gastric mucosal protective effect of AEPF is brought by inhibiting the gastric secretion, which shows it may act like a proton pump inhibitor. Thus the present study indicates that AEPF has anti-ulcerogenic potency in aspirin and pylorus ligation, cysteamine and cold restraint stress induced ulcers in rats.
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Author(s): B. V. S. Lakshmi, M. Sudhakar, Md. Imtiyaz