alexa Abstract | Evaluation of In Vitro Thrombolytic Activity of Ethanolic Extract of CURCUMA CAESIA Rhizomes


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Abstract

Thrombolytic agents dissolve blood clots and limit the damage caused by the blockage or occlusion of a blood vessel. These are widely used for the management of myocardial infarction, thromboembolic strokes, deep vein thrombosis and pulmonary embolism. Currently used synthetic drugs causes adverse effects such as major bleeding, cardiac arrhythmias, cerebrovascular hemorrhage and anaphylactic reaction, so there is a need to investigate some more safe natural thrombolytic agents. Present study is a preliminary work towards such endeavors. It was designed to investigate in vitro thrombolytic activity of ethanolic extract of Curcuma caesia rhizomes. An in vitro thrombolytic model was used to evaluate the clot lysis effect of ethanolic extract of Curcuma caesia rhizomes along with Streptokinase as a positive control and distilled water as a negative control. The ethanolic extract was found to have significant thrombolytic activity (49.18±3.41%) compared to the effect of Streptokinase (71.54±3.26%) used as a positive control and water (2.96±0.28%) used as a negative control. The current study refers the Curcuma caesia rhizomes as impressive thrombolytic agent for further used for the treatment of cardiovascular diseases. Therefore, steps should be taken to observe in vivo clot dissolving potential and to isolate active component(s) of these extracts which have Thrombolytic activity.

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Author(s): Syeda Nishat Fathima, Shaikh Vaquar Ahmad, B. Raj Kumar

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