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Research Article Open Access
Piroxicam is a nonsteroidal anti-inflammatory drug that is characterized by low solubility-high permeability and the rate of its oral absorption is often controlled by the dissolution rate in the gastrointestinal. The poor dissolution rate of water-insoluble drugs is still a major problem confronting the pharmaceutical industry there are several techniques to enhance the dissolution of poorly soluble drugs. Among them, the technique of liquisolid compacts is a promising technique towards such a novel aim. The present study was designed to improve the dissolution rate of non micronized piroxicam at the physiological pH's through its increased solubility by preparing liquid-solid dispersions of drug using triethyl citrate(TEC): acconon : polysorbate-80. The dissolution tests of the preparations were performed 1.2 pH simulating gastric using USP dissolution apparatus II. The concentration of the dissolved drug in the medium was determined by direct or first-derivative UV spectroscopy. The dissolution rates of the formulations were dependent on the nature and ratio of drug to carriers in SEDDS and the corresponding physical mixtures as well as the pH of the medium. Hence in the present study, it was attempted to evaluate non micronized Piroxicam formulation in the form of self emulsifying drug delivery system(SEDDS) technique. Formulation studies were performed to check the In Vitro study, Particle size analysis, Zeta potential, were performed. Hence it was concluded that SEDDS of Non Micronized piroxicam could be formulated.
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Author(s): Surya N. Singh, U. K. Patil