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Research Article Open Access
The main motto of present research was to develop a dual phasic tablet of Navirapine using super disintegratant micro crystalline cellulose for the fast release layer and water immiscible polymers such as Ethylcellulose, Xanthum gum for the sustaining layer. A dual component tablet made of a sustained release tabulated core and an immediate release tabulated coat was prepared by direct compression. Both the core and the coat contained a model drug Navirapine.. The sustained release effect was achieved with polymers like (HPMC) hydroxypropyl methylcellulose, (EC) Ethyl cellulose and Xanthan gum (XG) to sustain the release of Navirapine drug. The in-vitro drug release profile from these tablets showed the desired biphasic release behavior of Navirapine, where the fast releasing component was dissolved within 30 minutes and the drug in the core tablet was released over a period of 12 hours from the matrix tablets. It was observed that Xanthan gum is a better release retarding agent than HPMC and ethyl cellulose as it delayed the release of the drug for more than 15hrs. The results obtained with the dissolution test shows that the release profile is dependent on the type and amount of polymer in the core tablet.
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Author(s): Naresh Thamada, Prashanth Kumar.K, Bharath D, Srikanth Chowdhary P.
Dual component system ethylcellulose, immediate release, navirapine, xanthan gum, Liver Inflammation