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Review Article Open Access
The purpose of writing this review on floating drug delivery systems (FDDS) was to compile the recent literature with special focus on the principal mechanism of floatation to achieve gastric retention. Drug delivery systems are those that float immediately upon contact with gastric fluids present promising approaches for increasing the bioavailability of drugs with absorption windows in stomach or upper small intestine, unstable in the intestinal or colonic environment, and exhibit low solubility at high pH values. It is new drug delivery system maximize effectiveness and compliance. The Physiological problems like short gastric residence time and unpredictable gastric emptying time were overcome with the use of floating dosage forms which provide opportunity for both local and systemic effect. Floating drug delivery system enable prolonged and continuous input of the drug to the upper part of the gastro retention tract and improve the bioavailability of medication that is characterized by a narrow absorption window. This review article is in pursuit of giving detailed information on the pharmaceutical basis of their design, classification, advantages, in vitro and in vivo evaluation parameters, and application of floating systems, and applications of these systems. These systems are useful to several problems encountered during the development of a pharmaceutical dosage form and the future potential of FDDS. At attempt has been made in this review article to introduce the readers to current development in floating drug delivery system.
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Author(s): Pooja Gupta, Gnanarajan, Preeti Kothiyal
Gastric residence time, floating drug delivery system, classification, in-vitro evaluation, Liver Inflammation