alexa Abstract | Formulation and Evaluation of Bilayer Floating Tablet Containing Antihypertensive Drug


Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access

Abstract

Enalapril is an angiotensin converting enzyme (ACE) inhibitor used in the treatment of hypertension, diabetic nephropathy, and some types of chronic heart failure. The serum concentration profile of Enalapril exhibits a prolonged terminal phase apparently representing a small fraction of the administered dose that has been bound to ACE.The amount bound does not increase with dose, indicating a saturable site of binding. The effective half-life for accumulation of enalapril following multiple doses of enalapril maleate is 11 hours. The aim of the present investigation is to increase the gastric residence time by preparing gastro retentive floating bilayered tablet thereby by improving bioavailability. Fourier transform Infrared spectroscopy confirmed the absence of any drug/polymer interactions. Eight formulations (FE1 to FE8) were prepared using various polymers such as HPMC K15M, Sodium Carboxymethylcellulose in different ratios. Direct compression was adapted to compress bilayer floating tablet. The prepared bilayer floating tablet were evaluated for hardness, weight variation, thickness, Friability, drug content, buoyancy lag time, total floating time and in- vitro dissolution studies. Drug content (98.23-99.75%) was found uniform for all batches. percentage drug release was found to be 87.84 % to 97.27 % after 12 hours. Release of bi layered formulations follows zero order kinetics (0.8661 to 0.9649) except formulation FE1. When drug release data fitted to Korsmeyer equation, the values of slope ‘n’ (0.603 to 0.6981) indicated that the drug release was by non-fickian mechanism. FE4 was considered as optimized formulation which exhibited 84.91% of drug releases in 14 hours. The values were within the permissible limits.

To read the full article Peer-reviewed Article PDF image

Author(s): Anil Kumar AP, Felix Joe V., Vishwanath B. A

Recommended Journals

Share This Page

Additional Info

Loading
Loading Please wait..
 
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords