alexa Formulation and Evaluation of Fast Dissolving Tablets of Diclofenac Sodium Using PVP | Abstract

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In this research work, we are formulating a batch of tablets using Diclofenac sodium which is used as an NSAID’s in the treatment of Arthritis, inflammation and pain. We made different blends of super disintegrants with different ratio in fixed concentration were taken and tablets were formulated and evaluated with a view to optimize a formula and concentration blends of super disintegrants for Fast Disintegrating Tablets (FDT). In this research work three super disintegrants, viz. Cross carmellose, PVP were used. Six blends were prepared and 3 batches of tablets of each formulation code blend were formulated and evaluated for pre-compression parameters like Compressibility, Bulk density, Tapped density and post-compression parameters like Hardness, Weight variation, Disintegration time, Friability. Based on results it revealed that the formulation code blend A3 which had Cross carmellose, PVP in ratio 1:2 (4%w/w) emerged as best blend of super disintegrants for FDT formulation. To optimize the formula of A3 blend, Diclofenac sodium FDT was formulated and evaluated using the concentration blend of A3; three batches were formulated and evaluated for all above parameters and in-vitro drug release (pH7.4 phosphate buffer) and disintegration time was found between 34-37 seconds and release was more than 70% in 30 minute. We can conclude that a good FDT can be formulated using the above A3 blend concentration. All formulations are rapidly disintegrated in oral cavity as well as all formulations possess good NSAID’s properties.

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Author(s): Priyanka Khokhar, Vikesh Shukla

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