alexa Abstract | Formulation and Evaluation of Glyburide Liquisolid Compacts

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The intention of present research is to enhance the dissolution rate of water insoluble drugs like Glyburide. It is a poorly soluble drug and the rate of its oral absorption is often controlled by the dissolution rate in the gastrointestinal tract. There are several techniques to enhance the dissolution of poorly soluble drugs, in which the liquisolid compacts is a promising technique. Different formulations were prepared by using different vehicles and carriers and aerosil is used as the coating material. The empirical method as introduced by Spireas and Bolton was applied to calculate the amounts of coating and carrier materials required to prepare glyburide liquisolid tablets. Based upon this method, improved flow characteristics and hardness of the formulation has been achieved by changing the proportion of carrier and coating material ratio. In vitro dissolution profiles of the liquisolid formulations were studied and compared with conventional formulation in 0.1N HCl. It was found that liquisolid tablets formulated with PEG 400 and Avicel pH102 produced high dissolution profile and they showed significant higher drug release rates than conventional tablets due to increase in wetting properties and surface of drug available for dissolution. Drug-excipient interaction studies showed that there is no interaction between the drug and excipients. In conclusion, development of glyburide liquisolid tablets is a good approach to enhance the dissolution rate which increases bioavailability

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Author(s): Mohd Zahed Mohiuddin, Shankaraiah Puligilla, Saritha Chukka, Venkatratnam Devadasu, Jyothi Penta

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