alexa Abstract | Formulation and Evaluation of Metformin Based Niosomes

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Many active compounds have limited aqueous solubility, so there is great need for delivery systems suitable for hydrophobic and amphiphilic drugs. One approach to this problem has been to use lipid‐based vesicles as drug carriers. The history, properties, and applications of niosomes have been recently reviewed. Niosomes have been investigated for drug delivery through the most common routes of administration, such as intramuscular, intravenous, subcutaneous, ocular, oral, and transdermal. Niosomes appear to be multilamellar surfactant structures, and are thus best suited for hydrophobic or amphiphilic drugs. Niosomes are promising vehicle for drug delivery and being non‐ionic; it is less toxic and improves the therapeutic index of drug by restricting its action to target cells. They are vesicular systems similar to liposomes that can be used as carriers of amphiphilic and lipophilic drugs. Recently, niosomes have been studied by many researchers as a choice of oral drug delivery system to provide better oral bioavailability consideration, high penetration property of the niosome encapsulated agents through biological membrane and their stability. The present formulation study on metformin is an attempt to prepare niosomal drug delivery system and evaluate its in‐vitro Performance. The ormulations were prepared with different types of surfactant. The study is based on formulation of etformin nbility of metformin

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Author(s): M . Madhavi, C. P. Meher, B. Pochaiah, A. M. Rao

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