alexa Abstract | Formulation and In Vitro Evaluation of Fast Dissolving Tablet Containing Sildenafil Citrate Nanocrystals

Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access


Sildenafil citrate is a pharmacological agent which has proven useful in treatment of erectile dysfunction, pulmonary arterial hypertension as well as high altitude motion sickness. Sildenafil citrate exhibits an absolute bioavaibality of about 40% and is reported to result in maximum observed plasma concentration of about 30-120 minutes following after oral administration. Sildenafil citrate exhibits low water solubility,namely 3.5mg/ml. This low water solubility with its high presystemic metabolism have contributed to its low oral bioavailability. Thus,there is a need to to improve the bioavailability of sildenafil citrate. Fast dissolving tablet of sildenafil citrate were prepared with a intention to gain pre gastric absorption that will eliminate the presystemic metabolism of drug. Attempts were also made to improve the acqueous solubility of the drug by forming its nanocrystals. The nanocrystals of sildenafil citrate were formed by nanoprecipitation technique and were evaluated for particle size and shape by scanning electron microscopy and were also subjected to DSC and FTIR analysis.This formed nanocrystals were further considered as API for the fast dissolving tablet. The formulated F3 formulation(fast dissolving tablet containing cross povidone as polymer and sildenafil citrate nanocrystals) shows rapid drug release within 2 minutes as compared to the tablet containing pure drug

To read the full article Peer-reviewed Article PDF image

Author(s): Basim Deshmukh, Kantilal Narkhede, Pritam Chaudhari

Recommended Journals

Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version