alexa Abstract | Hepatoprotective Activity of Boerhavia Diffusa Linn. (Nyctaginaceae) against Ibuprofen Induced Hepatotoxicity in Wistar Albino Rats


Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access

Abstract

The present study was designed to evaluate the hepatoprotective activity of different parts of Boerhavia diffusa Linn. (Nyctaginaceae) such as root and aerial parts against ibuprofen (IB) induced hepatotoxicity in Wistar albino rats. Boerhavia diffusa L. is one of the well known folklore medicinal plants. The administration of ibuprofen (500mg/kg. b. wt.) produced significant changes in the normal hepatic cells, resulting in the formation of gastric lesions, centrilobular necrosis, vacuolization, and hepatomegaly. The adverse effect of ibuprofen was reflected in the levels of biochemical parameters of liver marker enzymes such as ALT, AST, ALP, and bilirubin. The activities of natural antioxidant enzymes like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and Glutathione-S-transferase (GST) were decreased significantly. The methanol extract (85%) of the root and aerial part of Boerhavia diffusa L. (500 mg/kg. b. wt.) produced remarkable changes in affected hepatic cell architecture and restored nearly normal structure and functions of hepatic cells. Similarly the different parts of the Boerhavia diffusa L. (500 mg/kg. b. wt.) restored the altered biochemical parameters of liver marker enzymes close to normal control levels. The observed results show the root of Boerhavia diffusa L. possesses more hepatoprotective efficacy than the aerial part of the same plant. The results suggest that the hydro alcoholic (15:85%) extract of Boerhavia diffusa L. possesses significant potential effect as a hepatoprotective agent.

To read the full article Peer-reviewed Article PDF image

Author(s): A. Jayavelu, A. Natarajan, S. Sundaresan, K. Devi3, B. Senthil kumar

Recommended Journals

Share This Page

Additional Info

Loading
Loading Please wait..
 
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords