alexa Abstract | Immunosuppressive and Cytotoxic Potential of Flavonoids from Mitragyna parvifolia, Mangifera indica and Aegle marmelos
e-ISSN: 2322-0139 p-ISSN: 2322-0120

Research & Reviews: Journal of Pharmacology and Toxicological Studies
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access


The objective of our study is to isolate the flavonoids from the leaves of these three medicinal plants and evaluated in vitro effect on human peripheral blood mononuclear cells (PBMC) using hepatitis B vaccine containing surface antigen (HBsAg; 20 µg/ml, 10 µl) and determined its HBsAg proliferation, nitric oxide production and CD14 monocyte surface marker. The results showed that flavonoids at higher doses (25 mg/ml; 50 µl) inhibited HBsAg stimulated proliferation of human PBMC cells as well as nitric oxide production and also blocked the activation of CD14 monocyte surface marker, which are necessary for T cell activation. Our results reporting the immunosuppressive activity of Mitragyna parvifolia, Mangifera indica and Aegle marmelos against HBsAg, specific protein antigen. Thus, these crude flavonoids isolated from medicinal plants could be a candidate for development as an immunosuppressive and cytotoxic agent.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Amit Gupta, Sushama R Chaphalkar


Mitragyna parvifolia, Mangifera indica, Aegle marmelos, Immunosuppression, Cytotoxicity, Pharmacology

Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version