alexa Abstract | Influence of Diluents on Diclofenac Sodium Release from Gum Kondagogu Based Matrix Tablets.


Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access

Abstract

The purpose of the study was to investigate the influence of formulation variables on the release profile of diclofenac sodium from gum kondagogu matrix tablets. Experimental design was applied to evaluate the influence of concentration of the gum and type of diluent with the final goal of drug release behavior optimization. Two independent variables considered were concentration of the gum (X1) and type of diluents (X2). The considered responses were the percentage drug released at three determined times (Q4, Q7, Q10), zero order rate constant and the time to release 50% of drug. Matrix tablets were prepared by wet granulation method. Physical properties and drug release studies were carried out for the prepared tablets. The physical properties indicated good handling properties of the prepared matrix tablets. Polynomial equations and response surface plots were generated for all dependent variables. The present study indicates that both the factors have a significant effect on drug release profile. The dissolution studies indicate the release behavior of all the formulations was super case II transport mechanism with zero order kinetics. The results demonstrate the reliability of the model in the preparation of matrix tablets of diclofenac sodium for sustained release using gum kondagogu with the selected diluents.

To read the full article Peer-reviewed Article PDF image

Author(s): Lakshmi Prasanna J, Deepthi B, Rama Raon

Recommended Journals

Share This Page

Additional Info

Loading
Loading Please wait..
 
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords