alexa Abstract | Influence of Poloxamer188 on the Intestinal Transport of Diltiazem Hydrochloride
ISSN ONLINE(2319-8753)PRINT(2347-6710)

International Journal of Innovative Research in Science, Engineering and Technology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access


Background: Many Excipients are known to interact with P - gp and CYP enzyme system thereby limiting the oral bioavailability. The present study was aimed to investigate the influence of polox amer 188(with different concentrations) pretreatment on the intestinal transp ort of Diltiazem Hydrochloride. Methods: The transport of Diltiazemacross different parts of rat intestine was studied by everted and non - everted sac methods. The control and poloxamer 188 (0.25%, 0.5% and 1% for 7 days) pre - treated rats were sacrificed an d isolated the intestine. The sacs of intestine were prepared, treated with Diltiazemsolution and then placed i n dulbeccos buffer. Samples were collected periodically and the drug content was estimated using HPLC. Results and conclusion: The results show that there was a significant (p<0.05) difference in the transport of Diltiazem from the intestinal sacs of pretreated with poloxamer 188 and control. Pretreatment with Poloxamer d ecreased drug exsorption in everted studies and increased transport in non ev erted studies compared to control indicating the inhibition of P - gp transporter and CYP3A enzyme respectively.

To read the full article Peer-reviewed Article PDF image

Author(s): Hafsa Rana, Sunitha B , Shravan Kumar Y* , Avinash M


Diltiazem, Poloxamer 188, Everted, Non Everted, Exsorption and High Performance Liquid Chromatography method (HPLC) ., Fluid Dynamics

Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version