alexa Abstract | Insilico Design, Synthesis and In vitro Antidiabetic and Anti- Inflammatory Activities of 1,3,4-Thiadiazole Substituted 2-Methyl Benzimidazole Derivatives


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Research Article Open Access

Abstract

Novel 1,3,4-thiadiazole substituted 2-methyl benzimidazole derivatives were designed by using various softwares such as ACD Lab ChemSketch 12.0, Molinspiration, PASS and Discovery studio. The designed molecules having required physico-chemical properties, drug likeness and obeying Lipinski’s rule of five (BT1, BT2, BT3, BT4, BT5, BT6, BT7, BT8 and BT9) were selected for the synthesis. These compounds were synthesized by conventional methods. All the synthesized compounds were confirmed based on their physicochemical parameters and their characteristic peaks in IR, 1HNMR and Mass spectroscopic studies. Based on the Libdock score, the compound BT6 was selected for in vitro antidiabetic and anti-inflammatory evaluation. The compound BT6 showed significant antidiabetic and anti-inflammatory activities.

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Author(s): Sandhya MJ Nair, Janeera Beevi, Merlin NJ, Bravin D Emmanuel, Shaiju S Dharan and Remya CR

Keywords

1,3,4-thiadiazole substituted 2-methyl benzimidazole derivatives, Insilico modeling, Spectral study, In vitro antidiabetic and antiinflammatory studies, Molecular Drug Design,Computational Chemistry,Alternative Medicines

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