alexa Abstract | Insilico Design, Synthesis and In vitro Antidiabetic and Anti- Inflammatory Activities of 1,3,4-Thiadiazole Substituted 2-Methyl Benzimidazole Derivatives

Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access


Novel 1,3,4-thiadiazole substituted 2-methyl benzimidazole derivatives were designed by using various softwares such as ACD Lab ChemSketch 12.0, Molinspiration, PASS and Discovery studio. The designed molecules having required physico-chemical properties, drug likeness and obeying Lipinski’s rule of five (BT1, BT2, BT3, BT4, BT5, BT6, BT7, BT8 and BT9) were selected for the synthesis. These compounds were synthesized by conventional methods. All the synthesized compounds were confirmed based on their physicochemical parameters and their characteristic peaks in IR, 1HNMR and Mass spectroscopic studies. Based on the Libdock score, the compound BT6 was selected for in vitro antidiabetic and anti-inflammatory evaluation. The compound BT6 showed significant antidiabetic and anti-inflammatory activities.

To read the full article Peer-reviewed Article PDF image

Author(s): Sandhya MJ Nair, Janeera Beevi, Merlin NJ, Bravin D Emmanuel, Shaiju S Dharan and Remya CR


1,3,4-thiadiazole substituted 2-methyl benzimidazole derivatives, Insilico modeling, Spectral study, In vitro antidiabetic and antiinflammatory studies, Molecular Drug Design,Computational Chemistry,Alternative Medicines

Recommended Journals

Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version