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Research Article Open Access
Syzygium zeylanicum (L.) DC is perennial evergreen shrub belongs to the family Myrtaceae having yellow flowers and dark green leaves. Traditionally leaf extracts has been used to treat various ailments such as joint pain, head ache, arthritis and fever. The traditional uses show that the plant is a good candidate for antioxidant related activity such as anti-inflammatory. The present study was to evaluate in-vitro anti-inflammatory activity of Syzygium zeylanicum leaves by inhibition of Cyclooxygenase, 5-lipoxygenase and by inhibition of protein denaturation. Successive solvent extraction of shade dried leaves were carried out using solvents of increasing polarity and all the extracts were subjected to estimation of total phenolics and the extract containing maximum of phenolics were subjected to anti-inflammatory studies. Preliminary phytochemical analysis was done on all extracts. Ethyl acetate extract and aqueous extract found to contain maximum of phenolics by Folin-ciocalteau method. Anti-oxidant activity study by using nitric oxide scavenging activity showed the ethyl acetate extract has maximum activity (IC50 = 125 mcg/ ml). The evaluation of anti-inflammatory activity by inhibition of Cyclooxygenase (70.71 and 78.79% at 100 and 500 mcg/ ml), 5-lipoxygenase (65.95 and 70.26% at 100 and 500 mcg/ ml) and by determination of protein denaturation (64.43 and 76.92% at 100 and 250 mcg/ml) showed the ethyl acetate extract possess good anti-inflammatory activity.
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Author(s): M. V. Anoop, A. R. Bindu
5-lipoxygenase, Anti-inflammatory, Cyclooxygenase, Folin-ciocalteau, Syzygium zeylanicum, Anti-inflammatory cytokines,Anti-inflammatory cytokines