alexa Abstract | In-vitro, Ex-vivo Skin Permeation and Biological Evaluation of 18-Β-Glycyrrhitic Acid Transdermal Patches


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Research Article Open Access

Abstract

 Objective: Transdermal patch is a promising approach that allows continuous input of drugs with short biological half-lives. 18 β-Glycyrrhitic acid (GA) is chemically pentacyclic triterpenoid which possess powerful anti-inflammatory action. The present study was designed to formulate GA reservoir-type transdermal patches using piperine as bioenhancer. Method: Transdermal Patch of GA was prepared using heat seal technique using 2*3 factorial design allowing for independent variables like penetration enhancers, formulation matrix and rate controlling membranes. The GA patches were evaluated for in-vitro and ex-vivo drug permeation through cellophane membrane and rat skin respectively. The biological evaluation regarding skin irritation study and the anti-inflammatory effect of GA patches on rat paw edema were tested and compared with standard Aceclofenac patch. Result: The reservoir-type patch of F4 formulation, containing 5% menthol as a permeation enhancer, 42% ethanol, 2% carbopol 934 gel bases (50 g) with 0.5% piperine provided an improved sustained release of phytopharmaceuticals through transdermal administration. The anti-inflammatory action F4 formulation showed no skin irritation with significant inhibition of rat paw edema compared with standard patch. Conclusion: The GA patch was demonstrated the feasibility for future biopharmaceutical study in clinical trials.

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Author(s): Prachi M. Patel, VH Bhaskar

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