alexa Abstract | Multicomponent Synthesis and Pharmacological Screening of 3-Cyano -4-Imino -2- Methylthio -8- Nitro -4H- Pyrimido [2,1-b] [1,3] Benzothiazole and its 2-Substituted Derivatives


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Abstract

Multicomponent reactions which are one pot reactions constitute an especially attractive recent synthetic strategy since they provide easy and rapid access to large number of organic compounds with diverse substitution pattern, we report multicomponent synthesis of novel fused heterocyclic compound, 3-cyano-4-imino-2-methylthio-8-nitro -4H- pyrimido [2,1-b] [1,3] benzothiazole and its 2-substituted derivatives. 2-Substituted derivatives of 3-cyano-4-imino-2-methylthio -8- nitro -4H- pyrimido [2,1-b] [1,3] benzothiazole have been prepared through One Step Multicomponent reaction by heating a mixture of 2-amino -6- nitro benzothiazole and bis methylthio methylene malononitrile independently with aromatic amines/phenols/heterylamines/ compounds containing active methylene group respectively in the presence of dimethyl formamide and catalytic amount of anhydrous potassium carbonate. All these newly synthesized compounds were characterized by IR, NMR, Mass spectroscopy and all the compounds were screened for antibacterial activity.

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Author(s): A. B. Chidrawar, G. S. Waghmare, R. U. Pokalwar, S. V. Kuberkar

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