alexa Novel Approaches for Brain Drug Delivery System-Review | Abstract

Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access


The brain is a delicate organ, and nature has very efficiently protected it. Drug delivery into the brain was difficult due to the existence of blood brain barrier, which only permits some molecules to pass through freely. The brain is shielded against potentially toxic substances by the presence of two barrier systems: the blood brain barrier (BBB) and the blood cerebrospinal fluid barrier (BCSFB). Unfortunately, the same mechanisms that protect it against intrusive chemicals can also frustrate therapeutic interventions. In past decades, nanotechnology has enabled much technical advancement, including drug delivery into the brain with high efficiency and accuracy. The challenging domain of effective brain delivery has led to a keen scientific pursuit and as a result many novel methods have been invented and patented. In the present paper, we summarize recent important advancements in employing nanotechnology for drug delivery. The technological strategies are essentially non-invasive methods of drug delivery to malignancies of the central nervous system (CNS) and are based on the use of nanosystems (colloidal carriers) such as liposomes, polymeric nanoparticles, solid lipid nanoparticles, polymeric micelles and dendrimer. Based on the current findings, it can be concluded that crossing of the BBB and drug delivery to CNS is extremely complex and require a multidisciplinary approach such as a close collaboration and common efforts among researchers of several scientific areas, particularly medicinal chemists, biologists and pharmaceutical technologists.

To read the full article Peer-reviewed Article PDF image

Author(s): Swatantra Bahadur Singh


Blood-brain barrier, nanoparticle, liposome, polymeric micelles and micro emulsions, molecular trojan horses., Liver Inflammation

Recommended Journals

Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version