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Research Article Open Access
In this modern era, gastrointestinal disorders are the universal problem. Diarrhea & dysentery is one of the major diseases affecting the human population. In developing countries, a quarter of infant and childhood mortality is related to the diarrhea. Number of factors, such as infective, immunological and nutritional has been involved in the perpetuation of the diarrheal syndrome. Many plants conveniently available in India are used in traditional folklore medicine for the treatment of diarrhoea and dysentery. In the present study, the crude aqueous extract of the entire plant of Croton sparsiflorus Morong. (Family- Euphorbiaceae) was evaluated for its possible phytochemical nature (group determination of plant constituents) and antidiarrhoeal activity. Phytochemical analysis of the aqueous extract of C. sparsiflorus indicated the presence of tannin, steroid & alkaloid types of compounds. The aqueous extract of C. sparsiflorus was studied for its antidiarrhoeal properties in experimental diarrhoea, induced by castor oil and magnesium sulphate in mice. At the doses of 250 and 500 mg/kg per oral, the aqueous extract showed significant and dose-dependent antidiarrhoeal activity in both models. The results were statistically significant (P <0.001) and was comparable to the standard drug atropine sulphate (0.1mg/kg; i.p.). The results showed that the extracts of C. sparsiflorus have a significant antidiarrhoeal activity and supports its traditional uses in herbal medicine.
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Author(s): Sanjay Kumar Yadav , Sanjib Das