alexa Abstract | Polyelectrolyte Complexes: Based Drug Delivery Devices

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Polyelectrolyte Complexes (PECs) are the association complexes formed due to the electrostatic interactions between oppositely charged particles. It is formed between cationic(Chitosan) polymers and oppositely charged anionic polymers. It forms amorphous aggregates, held together by reversible ionic/hydrophobic cross-links with predominantly random charge-compensation within the complex. The PECs particle sizes and surface charge can be maintained by varying the concentration of the polymers. IR spectroscopy, NMR, thermal analysis, pKa and X-ray diffraction, are used to evaluate the inter polymer complexation. Based on the structures, PECs can be categorized into different subtypes: soluble, colloidal stable and coacervate complexes. PECs can be used as membranes for coating on films and fibers, for isolation and fractionation of proteins, for isolation of nucleic acid, for binding pharmaceutical products, as supports for catalyst and for preparation of microcapsules for drug delivery. This paper gives a concise review of PECs formation and its application in the drug delivery technology. PECs can be used for the both the deliveries of immediate release (Phenytoin sodium) and as well as in controlled release (Propranolol HCL). PECs can be able to modify the release, improve the stability and character of the drug substances. Hence there is a great prospective in utilizing these PECs in biotechnology and Pharmaceutical technology.

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Author(s): Izhar Ahmed Syed, P. Niveditha.


Complexation, drug delivery devices, macromolecules, polyelectrolyte complexes, polymers, Liver Inflammation

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