alexa Preparation and Characterization of Tegaserod Maleate Containing Targeted Microspheres for Colonic Drug Delivery System. | Abstract
e-ISSN:2320-1215 p-ISSN: 2322-0112

Research & Reviews in Pharmacy and Pharmaceutical Sciences
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Research Article Open Access

Abstract

The aim of study was to develop and evaluate tegaserod maleate (TM) microspheres for colonic drug delivery system. Microspheres of TM were prepared by with little modification in the coacervation phase separation method by using polymer sodium alginate. These microspheres were evaluated for particle size, percentage drug entrapment and in-vitro drug release studies. The mean particle size of prepared microspheres was found to be in a range of 713.00 - 823.66 μm. Percentage drug entrapment observed in all formulations was between 62.28 - 66.88 %. In-vitro drug release studies showed that the release of tegaserod maleate from the microspheres was mainly influenced by the polymer concentration. It is concluded from the present investigation that TM-alginate microspheres are promising controlled release carriers for colon targeted delivery.

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Author(s): Mahesh S Nemade, Rajesh Y Chaudhari, and Vijay R Patil

Keywords

Tegaserod Maleate, Colonic Drug Delivery System, Microspheres, Prokinetic Agent, Drug Resistance,Drug Delivery Systems

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