alexa Abstract | Preparative Isolation and Antitumor Activity of Six Ginkgol Monomers from Ginkgo biloba
e-ISSN: 2321-6182 p-ISSN: 2347-2332

Research & Reviews: Journal of Pharmacognosy and Phytochemistry
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access


Ginkgols are bioactive compounds from Ginkgo biloba L., exhibiting excellent antitumor activity. For research on the structure-activity relationships, four ginkgol monomers (C13:0, C15:1-Δ8, C17:2-Δ9, 12, C15:0) and two ginkgol isomers (C17:1-Δ10, C17:1-Δ12) were isolated successively by preparative HPLC and identified. The results of MTT assay showed that all of the ginkgol monomers exhibited cytotoxicity against HepG2 and HGC cells. Ginkgol monomers with unsaturated side chains performed stronger inhibitory effects than which with saturated side chains. The IC50 values of ginkgol C15:1-Δ8, C17:2-Δ9, 12, C17:1-Δ10, C17:1-Δ12 on HepG2 and HGC cells were in sequence: 5.69 and 3.94, 19.95 and 11.09, 19.79 and 10.22, 22.76 and 11.4 μg/mL. Among which, ginkgol C15:1-Δ8 showed the strongest cytotoxicity with the lowest IC50 values. As for the two ginkgol C17:1 isomers, double bond at Δ10 performed higher antitumor activities than that at Δ12. The IC50 values of ginkgol C17:2 with two double bonds were close to that of ginkgol C17:1 with one double bond.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Pan-Jun Liu, Xiao-Ming Yang, Yue-Ying Li, Ya-Li Liu, Ya-Xiang Shi, Cun-Sheng Zhang


Ginkgo biloba L., Ginkgol, Isolation, Identification, Antitumor activity, Antitumor Activity

Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version