alexa Abstract | Prevalence of HCMV in Indian Scenario


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Abstract

A cytomegalovirus (HCMV) infection is one of the leading cause of morbidity in immunocompromised patients especially in solid organ transplant recipients (SOTRs). HCMV is found throughout all geographic locations and socioeconomic groups but it is more widespread in developing countries and in areas of low socioeconomic conditions. CMV is one of the most successful human pathogen, it can be transmitted vertically or horizontally and it is also known as Human herpes virus 5 (HHV-5). The endeavour of this study was to ascertain the prevalence of CMV in developing countries like India. Over a period of two years (October 2012- October 2014), 912 clinical specimens were received from various hospitals and clinics from diverse regions of India for screening of CMV as a part of routine testing. Among 912 specimens, only 900 specimens were tested and 12 specimens were not included in the study because these were rejected due to inappropriate specimen condition. Real time PCR assay was used for viral load estimation. On the basis of result of HCMV viral load detection of all 900 samples, we found 443 (49 %) CMV positive patients, out of those positive specimens, male positivity was 45.21% and female positivity was 59.72%. We found that the prevalence of cytomegalovirus was significantly higher in females as compared to males. Age wise correlation was also conducted. The highest age-specific cytomegalovirus prevalence i.e. 76.67 % was found in the age group of 21-30 followed by > or =60.

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Author(s): S. Shukla, P. Singh, P. Tidke, V. Bhatia, S. Dutt

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