alexa Abstract | Protective Role of Hydroalcoholic Extract of Vitis vinifera against Adriamycin Induced Cardiac, Renal and Hepatic Toxicities in Rat


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Abstract

Adriamycin (ADR) causes toxicities in heart, liver and kidneys via inducing the peroxidative alterations in organ tissues. Recent studies showed that Vitis vinifera exerts beneficial effects on heart, liver and kidney injuries induced by different pathological conditions. We hypothesize that Vitis vinifera extract (VVE) have a protective effect on ADR induced cardiac, renal and hepatic toxicities by inhibiting the peroxidative alterations in organ tissues. Total six groups of six animals each were divided into control, ADR (15mg/kg i.p. on 28th day), Vitamin E + ADR and VVE groups (100, 200 and 400 mg/kg for 30 days + ADR). After 4 weeks, the serum biochemistry variables were determined. ADR caused significant cardiac, renal and hepatic toxicities indicated by the serum biochemistry variables. The tissue MDA level in heart, kidney and liver in rats treated with ADR were markedly elevated, while GSH, SOD, CAT content in these tissues were significantly reduced. Vitis vinifera administration induced significant reduction of MDA level and increase of GSH, SOD, CAT content in all tissues. This study suggests that Vitis vinifera play an overall protective effect on ADR-induced toxicities in heart, liver and kidneys. Inhibition of tissue peroxidative alterations and detoxification of free radicals that are generated, might contribute to this beneficial effect

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Author(s): B. V. S. Lakshmi, M. Sudhakar , P. Shashank

Keywords

Adriamycin, heart, kidney, lipid peroxidation, liver, Vitis vinifera, Liver Inflammation,Cardiac Toxicity

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