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Review Article Open Access
Deep vein thrombo-embolic disease is often regarded as uncommon in Indians, but there is no objective evidence to support this view. Venous thromboembolism is a serious and frequent complication after all types of surgery, with venous thrombosis occurring in 40-60% of untreated patients, proximal vein thrombosis in 20- 40% and fatal pulmonary embolism in 1-3% of untreated patients. Severe prophylactic modalities have been shown to reduce the risk; including patients underwent surgery under general anaesthesia. The American College of Chest Physicians recommends low molecular weight heparin products for preventing deep vein thrombosis and pulmonary embolism among patients undergoing major surgery. In the absence of clinical evidence, experts continue to debate the equivalence of LMWHs in terms of pharmacologic properties and clinical outcomes. Prolonged thromboprophylaxis with LMWHs is justified for the improvement in clinical outcomes produced.
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Author(s): A. Tamil Selvan, N. Siva Subramanian