alexa Abstract | Role of Ethanolic Extract of Bauhinia purpurea Leaves on Ameliora- tion of Hyperthyroidism in LT4 Induced Female Albino wistar Rats
e-ISSN: 2322-0139 p-ISSN: 2322-0120

Research & Reviews: Journal of Pharmacology and Toxicological Studies
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Research Article Open Access

Abstract

Ethanolic extract of Bauhinia purpurea leaves was evaluated for its possible ameliorative effect in the regulation of hyperthyroidism in Albino wistar rat model. Serum triiodothyronine (T ), thyroxine (T ) and thyroid stimulating hormone (TSH) concentrations were considered as the end parameters of thyroid function in the study. Histopathological study of thyroid gland was also performed. LT administration (0.5 mg/kg/d for 12 days) as an inducing agent increased the levels of serum T , T with a concomitant decline in TSH 3 4 levels. However, simultaneous administration of the EEBP (100 mg/kg, 150 mg/kg 12-30th day) to the LT induced hyperthyroid animals reversed all these effects indicating their potential in the regulation of hyperthyroidism. PTU (10 mg/kg, 12-30th day) was administered as standard drug. PTU is selected as the standard drug in the light of many anti-thyroidic studies done. When relative efficacy was compared with that of propyl thiouracil (PTU), a standard antithyroidic drug, experimental B. purpurea extract appeared to be comparable. Furthermore histopathological analysis confirmed the result obtained.

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Author(s): Revathy R Nair, Litty Joseph and Rahees T

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