alexa Abstract | Simultaneous Estimation of Perindopril Erbumine and Indapamide in Combined Dosage form using Derivative Spectrophotometric Method

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A first-order derivative spectrophotometric method for the simultaneous determination of Perindopril erbumine and Indapamide in pharmaceutical dosage forms is described. Methanol was used as a solvent. First order derivative spectroscopy method was adopted to eliminate spectral interference, using 215nm and 241nm zero crossing points for Perindopril Erbumine and Indapamide respectively. The linear dynamic ranges were 1-5 μg ml−1 for Perindopril Erbumine and 2-20 μg ml−1 for Indapamide, the correlation coefficient for the calibration graphs were near to 0.9998, n=5, the precision (%RSD) was better than 1.43% and the accuracy was satisfactory (Er<0.99%). The detection limits were found to be 0.45 and 0.35 μg ml−1 for Perindopril Erbumine and Indapamide, respectively. The method was applied in the quality control of commercial tablets and proved to be suitable for rapid and reliable quality control. The results of analysis have been validated statistically and recovery studies confirmed the accuracy of the proposed method.

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Author(s): Tarkase K. N., Mahajan P. B., Suruse S. D.

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