alexa Abstract | Solid as solvent- Novel spectrophotometric analysis of naproxen tablets using melted phenol as solvent (Concept of mixed solvency)


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Abstract

The pollution and toxicity caused by most of the organic solvents is a big challenge. The researchers are doing much work to give eco-friendly solutions for this challenge. Maheshwari has given a nice concept, known as mixed-solvency concept. By application of this concept, innumerable solvent systems can be developed. Maheshwari is of the opinion that each substance possesses solubilizing power. He has given several eco-friendly methods in the area of drug estimations and formulations precluding the use of toxic organic solvents. The present investigation is an attempt to show that solids can also be wisely used to act as solvent precluding the use of organic solvents. Present study describes the application of solvent character of melted phenol (at 50-60°C) for spectrophotometric estimation of naproxen tablets. Solubility of naproxen in distilled water was found to be 0.09 mg/ml at room temperature. More than 140 mg of naproxen dissolved in one gram of melted phenol (at 50-60°C). In the present investigation, melted phenol (at 50-60°C) was utilized to extract out (dissolve) the drug from powder of naproxen tablets. Distilled water was used for dilution purpose. Absorbances of standard solutions containing 50,100, 150 and 200 μg/ml were noted at 331 nm against reagent blanks to obtain calibration curve. Proposed method is novel, economic, eco-friendly, rapid, free from toxicity of organic solvent, accurate and reproducible. Recovery studies and statistical data proved the accuracy, reproducibility and precision of the proposed method.

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Author(s): R. K. Maheshwari, Love Kumar Soni, Shailendra Singh Solanki

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